Hashing It Out Over Cannabis

Reaching out towards cannabis: approach-bias in heavy cannabis users predicts changes in cannabis use

AIMS Repeated drug exposure can lead to an approach-bias, i.e. the relatively automatically triggered tendencies to approach rather that avoid drug-related stimuli. Our main aim was to study this approach-bias in heavy cannabis users with the newly developed cannabis Approach Avoidance Task (cannabis-AAT) and to investigate the predictive relationship between an approach-bias for cannabis-relat...

Sorting it out

The AP-2 adaptor complex is widely viewed as a linchpin molecule in clathrin-mediated endocytosis, simultaneously binding both clathrin and receptors. This dual interaction couples cargo capture with clathrin coat assembly, but it has now been discovered that the association with cargo is tightly regulated. Remarkably, AP-2 is not obligatory for all clathrin-mediated uptake, and several alterna...

Just Out of It

Check it out!

Desmosomes sort it out

iochemical and kinetic studies have failed to provide a unified view on how the Arp2/3 complex nucleates actin filaments. Does the complex, which mediates actin filament nucleation and branch formation at the leading edge of motile cells, bind to the side of an older actin filament, or does it become incorporated into that filament? B Structural studies now add a new dimension to the discourse,...